Related Experiment Video

Updated: Aug 8, 2026

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

Progression to dementia in clinical subtypes of mild cognitive impairment

P Alexopoulos1, T Grimmer, R Perneczky

  • 1Department of Psychiatry and Psychotherapy, Technische Universitat, Munchen, Germany. palexopoulos@freemail.gr

Dementia and Geriatric Cognitive Disorders
|May 9, 2006
PubMed
Abstract

Insights

The type of mild cognitive impairment (MCI) significantly impacts dementia progression. Multiple-domain MCI shows a less favorable prognosis compared to amnestic MCI, suggesting an advanced prodromal stage.

Area of Science:

  • Neurology
  • Neuroscience
  • Geriatrics

Background:

  • Mild cognitive impairment (MCI) is a transitional stage between normal cognition and dementia.
  • Understanding MCI subtypes is crucial for predicting dementia risk.

Purpose of the Study:

  • To investigate the differential outcomes of various mild cognitive impairment (MCI) subtypes.
  • To assess the conversion rates to dementia across different MCI classifications.

Main Methods:

  • A longitudinal study followed 81 non-demented patients over 55 years old with MCI.
  • Patients were categorized into amnestic MCI, multiple-domain MCI, and single non-memory MCI.
  • Follow-up assessments were conducted over an average of 3.49 years.

Main Results:

  • Conversion to dementia rates varied significantly by MCI type: 25% for amnestic MCI, 54% for multiple-domain MCI, and 37.5% for single non-memory MCI.
  • The clinical subtype of MCI was a significant predictor of dementia conversion.
  • Multiple-domain MCI demonstrated the highest progression rate to dementia.

Conclusions:

  • Multiple-domain MCI indicates a less favorable prognosis than amnestic MCI.
  • Multiple-domain MCI may represent a more advanced prodromal stage of neurodegenerative dementia.
  • Clinical classification of MCI is essential for prognostic evaluation.

More Related Videos

The 4 Mountains Test: A Short Test of Spatial Memory with High Sensitivity for the Diagnosis of Pre-dementia Alzheimer's Disease06:23

The 4 Mountains Test: A Short Test of Spatial Memory with High Sensitivity for the Diagnosis of Pre-dementia Alzheimer's Disease

Published on: October 13, 2016

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans08:29

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans

Published on: December 18, 2016

Related Concept Videos

Dementia l: Introduction01:22

Dementia l: Introduction

Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...
Alzheimer Disease l: Introduction01:29

Alzheimer Disease l: Introduction

Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...
Dementia01:30

Dementia

Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual.
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
Cognitive Development During Adulthood01:30

Cognitive Development During Adulthood

Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
Alzheimer Disease ll: Pathophysiology01:23

Alzheimer Disease ll: Pathophysiology

Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and microglia. Abnormal...