Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Left ventricular function immediately following prolonged exercise: A meta-analysis.

Natalie Middleton1, Rob Shave, Keith George

  • 1Centre for Sports Medicine and Human Performance, Brunel University, Middlesex, United Kingdom.

Medicine and Science in Sports and Exercise
|May 9, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Participant lived experiences of high-intensity interval training in UK cardiac rehabilitation (HIIT or MISS UK): A qualitative study.

PloS one·2026
Same author

Time Series Response Analyser v2.0: A Web-Based Tool for Transparent Summary Statistics From Discrete Time-Series Data.

International journal of sport nutrition and exercise metabolism·2026
Same author

Individual oxidative stress and inflammation responses to vitamin C supplementation: Aggregated sets of n-of-1 trials.

Free radical biology & medicine·2026
Same author

Clinical Features and Outcomes of Treatment for Effusive Feline Infectious Peritonitis with GS-441524 in Seventeen Retrovirus-Positive Cats.

Pathogens (Basel, Switzerland)·2026
Same author

Feline plasma cell pododermatitis with concurrent glomerular disease: a case series of 25 cats.

Journal of feline medicine and surgery·2026
Same author

Assessing the impact of maternal blood pressure during pregnancy on perinatal health: a wide-angled Mendelian randomization study.

BMC medicine·2026
Same journal

Cardiorespiratory Fitness and Age-Related Decline in Kidney Function among Individuals with Preserved Kidney Health: The Aging Kidney Study.

Medicine and science in sports and exercise·2026
Same journal

Objectively Measured Cardiorespiratory Fitness as a Potential Biomarker for Alzheimer's Disease Risk in Older Adults: Evidence from the Generation 100 Study.

Medicine and science in sports and exercise·2026
Same journal

The Effects of Eight-Week Traditional Aerobic Exercise and Exergaming on Dual-Task Performance and Prefrontal Cortex Activation in Older Adults.

Medicine and science in sports and exercise·2026
Same journal

The Impact of Cardiorespiratory Fitness on Cytotoxic T Cell Metabolism and Function.

Medicine and science in sports and exercise·2026
Same journal

Female Athletes Through the Lifespan: Clinical Considerations and a Call for Comprehensive Sports Medicine Healthcare.

Medicine and science in sports and exercise·2026
Same journal

Artificial Intelligence in Exercise Science and Sports Medicine.

Medicine and science in sports and exercise·2026
See all related articles

Prolonged endurance exercise impairs cardiac function, reducing ejection fraction and altering diastolic filling. This meta-analysis reveals cardiac fatigue after intense exercise, suggesting impaired relaxation and systolic function.

Area of Science:

  • Cardiology
  • Exercise Physiology
  • Sports Medicine

Background:

  • Cardiac fatigue following prolonged endurance exercise is not well understood.
  • Previous studies have yielded equivocal results regarding its impact on left ventricular function.
  • A comprehensive analysis is needed to quantify these effects.

Purpose of the Study:

  • To conduct a meta-analysis examining the short-term effects of prolonged endurance exercise on left ventricular function.
  • To quantify changes in ejection fraction (EF), systolic blood pressure/end systolic volume (SBP/ESV) ratio, and early-to-late diastolic filling (E/A).

Main Methods:

  • A random effects meta-analysis of 23 studies was performed.
  • Data analyzed included EF, SBP/ESV, and E/A, along with heart rate (HR), systolic blood pressure (SBP), and left ventricular internal diameter during diastole (LVIDd).

Related Experiment Videos

  • Studies were categorized by exercise duration (moderate, long, ultra) and training status.

    • Main Results:

    • A significant overall decrease was observed in EF, SBP/ESV, and E/A (P < 0.05).
    • Reductions in EF were noted in ultra-duration and moderate-duration untrained subgroups.
    • All subgroups showed significant decreases in E/A, indicating impaired diastolic function.

    Conclusions:

    • Prolonged endurance exercise leads to reduced systolic function (decreased EF and SBP/ESV), partly due to altered cardiac loading.
    • A decrease in E/A suggests intrinsic impairment of left ventricular relaxation, independent of loading.
    • Future research should utilize load-independent indices and explore the underlying mechanisms of cardiac fatigue.