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Aldosterone impairs vascular endothelial cell function.

Yuko Hashikabe¹, Kunihiro Suzuki, Teruo Jojima

¹Department of Endocrinology and Metabolism, Dokkyo University School of Medicine, Mibu, Tochigi, Japan.

Journal of Cardiovascular Pharmacology

|May 9, 2006

Summary

Aldosterone directly impairs endothelial cell function by reducing nitric oxide production and increasing inflammatory markers. This dysregulation may contribute to high blood pressure and atherosclerosis.

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