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Mortality risk factors in chronic pancreatitis
Andrada Seicean1, Marcel Tantău, Mircea Grigorescu
13rd Medical Clinic, University of Medicine and Pharmacy, Str. Croitorilor no. 19-21, 400162 Cluj-Napoca, Romania. andradaseicean@yahoo.com
Summary
Mortality in chronic pancreatitis is elevated. Key risk factors for death include diabetes, persistent pain, and continued smoking, underscoring the need for comprehensive management strategies.
Area of Science:
- Gastroenterology
- Clinical Medicine
- Epidemiology
Background:
- Chronic pancreatitis (CP) is associated with higher mortality rates than the general population.
- Estimated 10-year survival post-diagnosis for CP ranges from 69-80%.
Purpose of the Study:
- To identify and evaluate mortality risk factors in patients diagnosed with chronic pancreatitis.
- To analyze survival rates and causes of death in a cohort of CP patients.
Main Methods:
- A cohort of 82 patients with chronic pancreatitis was followed for an average of 25 months.
- Patient data included age, sex, etiology (alcoholic, pancreas divisum, idiopathic), and treatment history.
- Mortality rates, causes of death, and survival curves were analyzed.
Main Results:
- The study observed a 17% mortality rate during the follow-up period.
- Leading causes of death included pancreatic cancer and surgical complications.
- Identified mortality risk factors were the presence of diabetes, unresolved pain, and ongoing smoking.
Conclusions:
- Mortality in this chronic pancreatitis cohort exceeded previously reported figures.
- Diabetes, persistent pain, and smoking cessation are critical risk factors influencing survival in CP.
- Pancreatic cancer was a significant cause of mortality, but no deaths were attributed to extra-pancreatic cancers.
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