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Neuropsychiatric and cognitive changes after surgery for primary hyperparathyroidism.
Cornelia M E Dotzenrath1, Ana Karena Kaetsch, Henrich Pfingsten
1Department of Surgery, St. Antonius-Kliniken, Vogelsangstrasse 106, 42109, Wuppertal, Germany. dotzenr@uni-duesseldorf.de
World Journal of Surgery
|May 9, 2006
Summary
Primary hyperparathyroidism (pHPT) often causes cognitive impairment and neuropsychiatric symptoms. Surgical treatment significantly improves cognitive function in pHPT patients, indicating a potential for long-term recovery.
Area of Science:
- Endocrinology
- Neurology
- Psychiatry
Background:
- Primary hyperparathyroidism (pHPT) is associated with neuropsychiatric symptoms and cognitive deficits.
- These manifestations significantly impact patient quality of life.
Purpose of the Study:
- To evaluate the long-term efficacy of surgical treatment for pHPT.
- To determine if parathyroid surgery leads to sustained recovery from cognitive and neuropsychiatric symptoms.
Main Methods:
- A prospective case-control study involving 30 pHPT patients and 30 controls.
- Preoperative and 6-month postoperative assessments using the Hamilton depression score and cognitive tests (DEM Tect, MWT, ZVT, Benton).
Main Results:
- pHPT patients exhibited significantly more cognitive changes compared to controls (P < 0.0001).
- Cognitive function significantly improved 6 months after parathyroid surgery (P < 0.0001).
- A tendency towards recovery of psychopathologic symptoms was observed in the pHPT group postoperatively.
Conclusions:
- Neuropsychiatric symptoms and cognitive impairment are common in pHPT.
- Successful parathyroid surgery demonstrably improves cognitive disorders in patients with pHPT.