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Updated: Aug 8, 2026

Automated Measurement of Pulmonary Emphysema and Small Airway Remodeling in Cigarette Smoke-exposed Mice
Published on: January 16, 2015
[Longitudinal decline of forced expiratory volume in one second in non-smoking Japanese women]
Masaru Nishitsuji1, Masaki Fujimura, Kazuhiko Shibata
1Internal Medicine, Koseiren Takaoka Hospital, Kanazawa University School of Medicine.
Abstract:
We prospectively studied 1,696 clinically healthy non-smoking women to assess the influence of aging on longitudinal decline in forced expiratory volume in one second (FEV10). All the subjects took an annually medical examination involving a pulmonary function test from 1995 to 2001. The mean value of annual decrease in FEV10 (slope) was 19.6 mL/year. Multiple regression analysis revealed that initial age, height, and FEV10 were significant parameters determining the slope. This study clearly showed the aging-related longitudinal decline in pulmonary function in non-smoking Japanese women.
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