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Related Experiment Videos

Pseudoscleroderma associated with cancer.

K Kikuchi1, T Hoashi, N Yazawa

  • 1Department of Dermatology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan. kikuchi-der@h.u-tokyo.ac.jp

Clinical and Experimental Dermatology
|May 10, 2006
PubMed
Summary

Pseudoscleroderma, a skin condition mimicking systemic sclerosis (SSc), can be linked to malignancies. This study found elevated basic fibroblast growth factor (bFGF) in pseudoscleroderma patients, suggesting a potential diagnostic marker.

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Area of Science:

  • Dermatology
  • Oncology
  • Biochemistry

Background:

  • Systemic sclerosis (SSc) is an autoimmune disease characterized by skin hardening.
  • Differentiating SSc from malignancy-associated pseudoscleroderma is crucial for patient management.
  • Investigating biomarkers for accurate diagnosis is an ongoing area of research.

Observation:

  • During 1994-2002, 71 patients with sclerotic skin changes were studied.
  • 66 patients were diagnosed with systemic sclerosis (SSc).
  • Five patients (7%) were diagnosed with pseudoscleroderma associated with malignancies.

Findings:

  • Pseudoscleroderma patients had shorter disease duration and fewer SSc-specific symptoms (antinuclear antibodies, Raynaud's phenomenon, esophageal involvement) compared to SSc patients.

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  • Serum basic fibroblast growth factor (bFGF) levels were significantly elevated in pseudoscleroderma patients versus controls.
  • Elevated bFGF expression was found in affected skin fibroblasts and lung cancer tissue.

    • Implications:

    • Elevated bFGF may serve as a biomarker to distinguish malignancy-associated pseudoscleroderma from systemic sclerosis.
    • Early identification of pseudoscleroderma can facilitate timely diagnosis and treatment of underlying cancers.
    • Further research into bFGF's role in pseudoscleroderma pathogenesis is warranted.