[The cholinergic modulation of the pressor reaction to angiotensin]

I.v. administration of acetylcholine or acetylcholine plus neostigmine produced a dose-dependent decrease of angiotensin pressor response to 59.2, 39.9, and 26.8% of basal level at 10(-7), 10(-6), and 10(-5) M/kg, resp., and to 76.4 and 56.7% of basal level at 10(-6) and 10(-5) M/kg of neostigmine in anesthetized rats. Atropine prevented these effects and increased the angiotensin pressor response to 142.1 and 168.9% of basal level at 10(-7) and 10(-6) M/kg, resp., in intact rats. The cholinergic system seems to attenuate angiotensin effect on arterial pressure.