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Updated: Aug 8, 2026

A Novel Pavlovian Fear Conditioning Paradigm to Study Freezing and Flight Behavior
Published on: January 5, 2021
Genes and neurons: molecular insights to fear and anxiety
C Stoppel1, A Albrecht, H-C Pape
1Institute of Physiology, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.
Abstract:
Experimental animal models provide an important tool for the identification of inheritable components of fear and anxiety. 'Pavlovian' fear conditioning has been tremendously successful to characterize the neuronal circuitry and cellular mechanisms of the formation, consolidation and extinction of fear memories. Here we summarize recent progress that has led to the identification of gene products contributing to such experience-dependent changes in fear and anxiety and may guide the search for genetic factors involved in the development and treatment of human anxiety disorders.
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