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The second messenger cascade in olfactory receptor neurons.

H A Bakalyar¹, R R Reed

¹Howard Hughes Medical Institute, Johns Hopkins School of Medicine, Baltimore, Maryland.

Current Opinion in Neurobiology

|August 1, 1991

Summary

The cAMP cascade and inositol trisphosphate act as crucial second messengers in sensory perception. Their interaction enhances the sensitivity of the olfactory system.

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Area of Science:

Molecular biology
Neuroscience
Biochemistry

Background:

The cyclic adenosine monophosphate (cAMP) cascade is vital for sensory transduction.
Inositol 1,4,5-trisphosphate is emerging as a key player in olfactory signaling.

Purpose of the Study:

To investigate the roles of cAMP and inositol 1,4,5-trisphosphate in sensory transduction.
To explore the potential interaction between these two signaling pathways in the olfactory system.

Main Methods:

Molecular cloning of signaling pathway components.
Biochemical characterization of identified proteins.

Main Results:

Components of the cAMP cascade have been successfully cloned and characterized.
Evidence indicates inositol 1,4,5-trisphosphate acts as a second messenger in olfaction.

Conclusions:

The cAMP cascade and inositol 1,4,5-trisphosphate are important for sensory transduction.
The interplay between these pathways likely enhances olfactory system sensitivity.

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