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Catheter-related thrombosis associated with elevated factor VIII levels in cystic fibrosis

D J Serisier1, M P Carroll

  • 1Department of Respiratory Medicine, Mater Adult Hospital, Brisbane, 4101, Australia; Adult Cystic Fibrosis Unit, Southampton General Hospitals NHS Trust, UK. david_serisier@mater.org.au <david_serisier@mater.org.au>

Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society
|May 10, 2006
PubMed

We report a cystic fibrosis (CF) subject with extensive, central venous catheter-associated thrombosis and sustained elevation of factor VIII to levels normally associated with significantly increased risks of deep venous thrombosis. To determine the potential significance of this finding, the prevalence of elevated factor VIII levels in 22 adults with CF was investigated. Mean (S.D.) factor VIII level was 177 (43) U/dl, with 77% of subjects having levels >150 U/dl. The high prevalence of elevated factor VIII levels questions the significance of this finding in CF subjects with catheter-related thrombosis.

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