Pit patterns in rectal mucosa assessed by magnifying colonoscope are predictive of relapse in patients with quiescent ulcerative colitis
- Y Nishio 1, T Ando , O Maeda , K Ishiguro , O Watanabe , N Ohmiya , Y Niwa , K Kusugami , H Goto
- 1Department of Gastroenterology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan. takafumia-gi@umin.ac.jp.
- 0Department of Gastroenterology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan. takafumia-gi@umin.ac.jp.
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View abstract on PubMed
Summary
This summary is machine-generated.Magnifying colonoscopy (MCS) grading of rectal pit patterns can predict ulcerative colitis relapse. Higher MCS grades correlate with increased inflammation and predict a greater risk of future disease exacerbation.
Area Of Science
- Gastroenterology
- Endoscopy
- Inflammatory Bowel Disease Research
Background
- Predicting ulcerative colitis (UC) relapse is challenging with standard colonoscopy.
- High-resolution video-magnifying colonoscopy with chromoscopy allows detailed observation of colorectal mucosal pit patterns.
Purpose Of The Study
- To assess the link between magnifying colonoscopy (MCS) pit patterns and histological inflammation/mucosal chemokine activity in quiescent UC.
- To identify prognostic factors for predicting UC exacerbations prospectively.
Main Methods
- Magnifying colonoscopy (MCS) performed on 113 UC patients in remission.
- Rectal mucosal pit patterns classified into four MCS grades.
- Mucosal interleukin-8 (IL-8) activity and histological activity assessed from biopsy specimens.
- Patients followed for relapse over 12 months; multivariate survival analysis used.
Main Results
- MCS grade positively correlated with histological grade (p=0.001) and IL-8 activity (p<0.001).
- MCS grade significantly predicted relapse (RR 2.06, p=0.001).
- Relapse rates increased with MCS grade: 0% (grade 1), 21% (grade 2), 43% (grade 3), 60% (grade 4) over 12 months.
Conclusions
- MCS grading correlates with histological inflammation and IL-8 activity in quiescent UC.
- MCS grading shows potential as a predictor for subsequent ulcerative colitis relapse in patients in remission.
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