Related Experiment Video

Updated: Aug 8, 2026

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4
12:09

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4

Published on: December 31, 2013

Regulation of TRPV5 and TRPV6 by associated proteins

Stan F J van de Graaf1, Joost G J Hoenderop, René J M Bindels

  • 1Department of Physiology, Radboud Univ. Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands.

American Journal of Physiology. Renal Physiology
|May 10, 2006
PubMed

Insights

Epithelial calcium channels TRPV5 and TRPV6 are key regulators of calcium homeostasis. Understanding their regulation by associated proteins is crucial for calcium balance and related diseases.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Physiology

Background:

  • Epithelial calcium channels TRPV5 and TRPV6 are crucial for active calcium transport.
  • These channels are central to hormonal regulation of calcium flux between lumens and blood.

Purpose of the Study:

  • To review the regulation of TRPV5 and TRPV6 channels.
  • To elucidate the role of associated proteins in TRPV5/6 regulation.
  • To connect channel regulation with calcium homeostasis.

Main Methods:

  • Literature review of TRPV5 and TRPV6 channel regulation.
  • Analysis of studies on TRPV5/6-associated proteins.
  • Synthesis of information on regulatory mechanisms.

Main Results:

  • TRPV5 and TRPV6 are highly calcium-selective TRP channels.
  • Associated proteins significantly influence TRPV5/6 function and regulation.
  • Regulation of these channels is complex and involves multiple factors.

Conclusions:

  • Understanding TRPV5/6 regulation is vital for calcium homeostasis.
  • Associated proteins are key players in TRPV5/6 channel function.
  • Further research into these mechanisms can inform therapeutic strategies.

More Related Videos

A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice08:35

A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice

Published on: March 17, 2015

Related Concept Videos

Thermosensation01:43

Thermosensation

Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
GTPases and their Regulation02:14

GTPases and their Regulation

Guanine nucleotide-binding proteins (G-proteins), also known as GTPases, are a superfamily of proteins that regulate many cellular processes, such as cell signaling, vesicular transport, and the regulation of cell shape and motility. Mutation or dysfunction of these proteins can lead to disease. There are around 40,000 known G-proteins that can broadly be classified into two groups ‒  small G-proteins consisting of a single domain and large multi-domain G-proteins.
Large G-proteins, also known...
GTPases and their Regulation02:14

GTPases and their Regulation

Guanine nucleotide-binding proteins (G-proteins), also known as GTPases, are a superfamily of proteins that regulate many cellular processes, such as cell signaling, vesicular transport, and the regulation of cell shape and motility. Mutation or dysfunction of these proteins can lead to disease. There are around 40,000 known G-proteins that can broadly be classified into two groups ‒  small G-proteins consisting of a single domain and large multi-domain G-proteins.
Large G-proteins, also known...
GPCRs Regulate Adenylyl Cylase Activity01:09

GPCRs Regulate Adenylyl Cylase Activity

Some GPCRs transmit signals through adenylyl cyclase (AC), a transmembrane enzyme. AC helps synthesize second messenger cyclic adenosine monophosphate (cAMP). AC catalyzes cyclization reaction and converts ATP to cAMP by releasing a pyrophosphate. The pyrophosphate is further hydrolyzed to phosphate by the enzyme pyrophosphatase, which drives cAMP synthesis to completion. However, cAMP is rapidly degraded to 5′ AMP by the enzymes phosphodiesterase (PDE), preventing overstimulation of cells.
Two...