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Postural effects on interstitial fluid pressure in humans.

Marc J Husmann1, Matthias Barton, Beatrice R Amann-Vesti

  • 1Division of Angiology, University Hospital Zurich, Zurich, Switzerland. husmann@gmx.ch

Journal of Vascular Research
|May 10, 2006
PubMed
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Interstitial fluid pressure (IFP) in the skin is higher when sitting compared to lying down. This difference is influenced by how long a person has been upright, impacting edema research.

Area of Science:

  • Physiology
  • Edema Pathophysiology

Background:

  • Understanding lower limb edema mechanisms requires assessing interstitial fluid pressure (IFP) changes with posture.
  • Previous IFP measurement techniques were invasive and limited acute assessments.

Purpose of the Study:

  • To directly assess the effect of postural changes on human skin interstitial fluid pressure (IFP).
  • To investigate IFP using the minimally invasive servonulling technique.

Main Methods:

  • The servonulling micropressure system was used to measure IFP in the skin of the foot.
  • Measurements were conducted in 12 healthy subjects in both sitting and supine positions.

Main Results:

  • Interstitial fluid pressure (IFP) was significantly higher in the sitting position (5.1 +/- 2.9 mm Hg) versus supine (-0.3 +/- 3.6 mm Hg) when measured in sitting first (p=0.04).

Related Experiment Videos

  • The order of measurement influenced the results; no significant difference was found when measuring supine first (p=0.46).
  • Low-frequency pressure fluctuations were more frequent in the sitting position (58%) than supine (33%, p=0.001).

    • Conclusions:

    • The servonulling micropressure system allows direct assessment of postural effects on IFP.
    • IFP is elevated in the sitting position, with the magnitude influenced by the duration of the upright posture.