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Informatic Analysis of Sequence Data from Batch Yeast 2-Hybrid Screens
Published on: June 28, 2018
Functional annotation and analysis of Korean patented biological sequences using bioinformatics
Byung Wook Lee1, Tae Hyung Kim, Seon Kyu Kim
1National Genome Information Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-333, Korea.
Molecules and Cells
|May 10, 2006
Summary
Korean patented biological sequences are increasingly common. Bioinformatic analysis reveals genes involved in hormonal defense responses are highly targeted for patenting, with 2.6% of human genes linked to Korean patents.
Area of Science:
- Bioinformatics
- Intellectual Property Law
- Molecular Biology
Background:
- The Korean Intellectual Property Office (KIPO) reports a significant rise in biological sequence-based patents in Korea.
- Understanding the biological characteristics of these patented sequences is crucial for tracking innovation and potential applications.
Purpose of the Study:
- To perform a bioinformatic analysis of Korean patented biological sequences.
- To identify the biological features, including associated genes, diseases, pathways, and functions, of these patented sequences.
Main Methods:
- Annotation of patented sequences against the Reference Sequence (RefSeq) database.
- Association analysis linking sequences to Entrez Gene, Online Mendelian Inheritance in Man (OMIM), Kyoto Encyclopedia of Genes and Genomes (KEGG), and Gene Ontology (GO) databases.
- Comparative analysis with US patent data.
Main Results:
- Approximately 2.6% of human genes are associated with Korean patenting, contrasting with 20% in US patents.
- Genes encoding products acting as hormones in extracellular defense responses represent the most frequently patented.
- The analysis identified key biological functions and pathways targeted by Korean patent applications.
Conclusions:
- Bioinformatic analysis provides valuable insights into the landscape of biological sequence patenting in Korea.
- Hormone-related genes involved in defense mechanisms are a major focus of Korean patenting efforts.
- The findings highlight specific areas of biological research and development being prioritized for intellectual property protection in Korea.
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