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Related Experiment Video

Updated: Jul 12, 2026

Localization and Relative Quantification of Carbon Nanotubes in Cells with Multispectral Imaging Flow Cytometry

Localization and Relative Quantification of Carbon Nanotubes in Cells with Multispectral Imaging Flow Cytometry

Published on: December 12, 2013

Interfacing carbon nanotubes with living cells.

Xing Chen¹, Un Chong Tam, Jennifer L Czlapinski

¹Department of Chemistry, University of California, Berkeley, California 94720, USA.

Journal of the American Chemical Society

|May 11, 2006

Summary

Researchers created a novel polymer coating for carbon nanotubes (CNTs) that mimics cell surfaces. This biomimetic coating makes CNTs nontoxic and enables binding to cell receptors.

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Last Updated: Jul 12, 2026

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Area of Science:

Biomaterials Science
Nanotechnology
Cell Biology

Background:

Carbon nanotubes (CNTs) offer unique properties but face challenges with biocompatibility and targeted cellular interaction.
Mammalian cell surfaces are coated with mucin glycoproteins, mediating crucial biological interactions.

Purpose of the Study:

To develop a polymer coating for carbon nanotubes (CNTs) that replicates the mucin glycoprotein layer of mammalian cells.
To impart biomimetic interaction capabilities and enhance the biocompatibility of CNTs.

Main Methods:

Synthesis of a polymer coating designed to mimic mucin glycoproteins.
Characterization of the coated CNTs for their interaction with cell surface receptors.
Assessment of the cytotoxicity of the modified CNTs on mammalian cells.

Main Results:

The developed polymer coating successfully mimics the mucin glycoprotein layer.
Coated CNTs exhibit the novel property of binding to carbohydrate receptors on cell surfaces.
Importantly, the polymer coating renders the carbon nanotubes nontoxic to cells.

Conclusions:

The novel mucin-mimicking polymer coating transforms carbon nanotubes into biocompatible materials.
This biomimetic approach enables targeted cellular interactions via carbohydrate receptor binding.
The developed coated CNTs hold potential for advanced biomedical applications requiring cell surface interaction.