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Antiglucocoticoid treatments for depression
1Department of Psychiatry, University of British Columbia, Vancoover, BC Canada. alyoung@interchange.ubc.ca
The Australian and New Zealand Journal of Psychiatry
|May 11, 2006
Summary
Antiglucocorticoid treatments show promise for depression by targeting the hypothalamic-pituitary-adrenal (HPA) axis. Lowering cortisol or blocking its effects may improve depressive symptoms and cognitive function.
Area of Science:
- Neuroendocrinology
- Psychiatry
- Pharmacology
Background:
- Hypothalamic-pituitary-adrenal (HPA) axis dysfunction and hypercortisolaemia are common in bipolar and unipolar depression.
- Impaired glucocorticoid receptor negative feedback may contribute to depressive symptoms and neurocognitive deficits.
Purpose of the Study:
- To review literature on antiglucocorticoid treatments for depression.
- To explore strategies counteracting elevated cortisol levels.
Main Methods:
- Selective literature review.
Main Results:
- Research focuses on strategies to counteract elevated cortisol and restore HPA axis integrity.
- Preclinical and clinical studies indicate potential therapeutic benefits.
Conclusions:
- Lowering circulating cortisol or using glucocorticoid antagonists may improve depressive symptoms.
- These approaches may also enhance neurocognitive function in depressed individuals.
- Up-regulation of glucocorticoid receptors is a potential mechanism of action.
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