Related Experiment Video
Updated: Aug 8, 2026
06:18
A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials
Published on: March 3, 2023
Total joint replacement in patients with inhibitors
L P Solimeno1, O S Perfetto, G Pasta
1Department of Orthopaedics, Hemophilic Arthropathy Treatment Centre M.G. Gatti-Randi, Milan, Italy. luigi.solimeno@icp.mi.it
Summary
Total joint replacement is standard for chronic haemophilic arthropathy without inhibitors. Future goals include expanding surgical access for haemophilic patients with inhibitors, mirroring current standards.
Area of Science:
- Orthopedic Surgery
- Hematology
Background:
- Total joint replacement is the standard treatment for chronic haemophilic arthropathy in the knee and hip.
- Surgical intervention for haemophilic patients with inhibitors remains limited due to high bleeding risks and treatment costs.
Purpose of the Study:
- To highlight the disparity in surgical access for haemophilic patients with and without inhibitors.
- To advocate for equitable surgical intervention possibilities for all haemophilic patients.
Main Methods:
- Review of current surgical practices and treatment advancements for haemophilic arthropathy.
- Analysis of the impact of activated recombinant factor VII on surgical procedures.
- Examination of cost-effectiveness of replacement therapies.
Main Results:
- While total joint replacement is routine for haemophilic arthropathy without inhibitors, it is not yet widely available for patients with inhibitors.
- Activated recombinant factor VII has enabled some surgical procedures, but high costs remain a barrier.
- Centers with extensive experience are routinely performing these surgeries.
Conclusions:
- Ensuring equal surgical intervention possibilities for haemophilic patients with and without inhibitors is a critical future goal.
- Increased patient numbers and accumulated experience in specialized centers are paving the way for routine surgeries in haemophilic patients with inhibitors.
Related Concept Videos
01:26Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy
Continuous Renal Replacement Therapy (CRRT) is an essential intervention for patients experiencing severe kidney dysfunction. This therapy offers a continuous mechanism for removing fluids and toxins from the bloodstream, leveraging the patient’s blood pressure to facilitate filtration through a specialized filter. This method contrasts with intermittent dialysis, providing a gentler and more consistent removal of waste products and excess fluid, which is particularly beneficial in critically...
01:26Kidney Transplant II: Surgical Procedure
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
01:28Kidney Transplant I: Introduction
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
01:16Kidney Transplant III: Nursing Management
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...