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Valvular surgery in Behcet's disease.

Vedat Erentug¹, Adil Polat, Nilgun Ulusoy Bozbuga

¹Kosuyolu Heart and Research Hospital, Istanbul, Turkey.

Journal of Cardiac Surgery

|May 11, 2006

Summary

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Behcet's disease patients undergoing valve replacement require strict anticoagulation due to hypercoagulability. Bileaflet mechanical valves are recommended for these patients to minimize risks.

Area of Science:

Cardiovascular Surgery
Rheumatology
Hematology

Background:

Behcet's disease is a chronic inflammatory condition associated with a hypercoagulable state.
Intracardiac masses in Behcet's disease patients may indicate thrombus formation.
Valvular disease necessitates surgical intervention in some Behcet's disease patients.

Purpose of the Study:

To analyze outcomes of Behcet's disease patients who underwent surgical valve replacement.
To evaluate the safety and efficacy of mechanical bileaflet prostheses in this patient population.
To emphasize the importance of managing hypercoagulability during cardiac surgery.

Main Methods:

Retrospective analysis of three Behcet's disease patients (1 male, 2 female) who underwent valve replacement.

Related Experiment Videos

Aortic valve replacement in two patients and mitral valve replacement in one patient using mechanical bileaflet valves.

Continued steroid therapy postoperatively and strict anticoagulation with warfarin (target INR 3-3.5).

Main Results:

No early or late mortality observed.
Uneventful intraoperative and postoperative courses for all patients.
One late cerebrovascular accident occurred 40 months post-mitral valve replacement, despite a functional prosthesis.

Conclusions:

Hypercoagulability in Behcet's disease necessitates stringent anticoagulation protocols.
Mechanical bileaflet prostheses are recommended for valve replacement in Behcet's disease patients.
Careful patient selection and management are crucial for successful outcomes.