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Updated: Jul 28, 2026

Controlled Cortical Impact Model for Traumatic Brain Injury
Published on: August 5, 2014
Do corticosteroids damage the brain?
J Herbert1, I M Goodyer, A B Grossman
1Department of Physiology, Development and Neuroscience, and Cambridge Centre for Brain Repair, University of Cambridge, Cambridge, UK. jh24@cam.ac.uk
Abstract:
Corticosteroids are an essential component of the body's homeostatic system. In common with other such systems, this implies that corticosteroid levels in blood and, more importantly, in the tissues remain within an optimal range. It also implies that this range may vary according to circumstance. Lack of corticosteroids, such as untreated Addison's disease, can be fatal in humans. In this review, we are principally concerned with excess or disturbed patterns of circulating corticosteroids in the longer or shorter term, and the effects they have on the brain.
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