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Olaquindox and cyadox stimulate growth and decrease intestinal mucosal immunity of piglets orally inoculated with
1National Reference Laboratory of Veterinary Drug Residues/MOA Key Laboratory of Food Safety Evaluation, Huazhong Agricultural University, Wuhan, Hubei, China.
Journal of Animal Physiology and Animal Nutrition
|May 11, 2006
Summary
The study found that olaquindox and cyadox improved piglet growth and feed conversion. These antimicrobials reduced intestinal immune cell counts, suggesting a role in growth promotion by suppressing immune activation.
Area of Science:
- Animal Science
- Immunology
- Veterinary Medicine
Background:
- Antimicrobials like olaquindox and cyadox are used in livestock for growth promotion.
- Escherichia coli infections can negatively impact piglet growth and intestinal health.
- Understanding the impact of these antimicrobials on the intestinal immune system is crucial.
Purpose of the Study:
- To investigate the effects of olaquindox and cyadox on piglet growth performance.
- To assess the impact of these antimicrobials on the intestinal immune response, specifically intraepithelial lymphocytes and immunoglobulin A secreting cells (ASCs).
- To determine if these antimicrobials modulate the immune response to Escherichia coli inoculation.
Main Methods:
- A 2x3 factorial design was used with 150 piglets, involving Escherichia coli inoculation and dietary supplementation with no antimicrobials, 100 mg/kg olaquindox, or 100 mg/kg cyadox.
- Growth parameters including average daily gain and feed conversion ratio (FCR) were measured over a three-week period.
- Intestinal immune cell populations (intraepithelial lymphocytes and ASCs) were quantified.
Main Results:
- Both olaquindox and cyadox significantly improved average daily gain and FCR (p < 0.01).
- Cyadox supplementation resulted in better average daily gain and FCR compared to olaquindox (p < 0.05).
- Dietary supplementation with antimicrobials decreased intraepithelial lymphocytes and ASCs (p < 0.05), with cyadox showing lower jejunal ASCs than olaquindox (p < 0.05).
Conclusions:
- Olaquindox and cyadox enhance piglet growth performance.
- These antimicrobials suppress E. coli-induced intestinal immune activation, indicated by reduced lymphocyte and ASC counts.
- The suppression of intestinal immunity may be a mechanism contributing to the growth-promoting effects of olaquindox and cyadox in piglets.
