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Updated: Aug 8, 2026

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
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Published on: May 28, 2014

Structure-toxicity relationships for different types of dinuclear platinum complexes

Ganna V Kalayda1, Sarah Fakih, Helga Bertram

  • 1Leiden Institute of Chemistry, Gorlaeus Laboratories, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands.

Journal of Inorganic Biochemistry
|May 11, 2006
PubMed
Summary

Platinum drug toxicity in kidney cells depends on where they enter. Basolateral exposure is toxic, while apical exposure is not, due to differences in cell membrane uptake. Structure impacts toxicity.

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