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Soy isoflavones modulate immune function in healthy postmenopausal women
Tracy A Ryan-Borchers1, Jean Soon Park, Boon P Chew
1Department of Food Science and Human Nutrition, Washington State University, Pullman, WA 99164-6376, USA.
The American Journal of Clinical Nutrition
|May 11, 2006
Summary
Soy isoflavones, found in soymilk and supplements, enhance B cell populations and protect against DNA damage in postmenopausal women. This study highlights potential immune benefits during menopause.
Area of Science:
- Immunology and Nutritional Science
- Menopause Research
- Oxidative Stress Studies
Background:
- Postmenopausal immune system decline is linked to aging and reduced estrogen.
- Soy isoflavones offer potential estrogenic and antioxidant benefits.
Purpose of the Study:
- To assess soy isoflavones' impact on immune markers and oxidative stress.
- Investigated effects of soymilk and supplement forms in postmenopausal women.
Main Methods:
- 16-week double-blind, placebo-controlled trial with 52 postmenopausal women.
- Three groups: control (cow milk), soymilk (isoflavones), or isoflavone supplement.
- Measured immune variables, including lymphocyte subsets and oxidative damage markers.
Main Results:
- Isoflavone intake increased B cell populations (P < 0.05).
- Reduced plasma 8-hydroxy-2-deoxy-guanosine, a DNA damage marker (P < 0.05).
- No significant changes in key cytokines or inflammation markers observed.
Conclusions:
- Soy isoflavones, in soymilk or supplements, modulate immune cell populations.
- Isoflavones demonstrate protective effects against DNA damage in postmenopausal women.
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