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Toward a core nutraceutical program for cancer management.

Mark F McCarty¹, Keith I Block

¹Block Center for Integrative Cancer Care, Evanston, IL 60201, USA. mccarty@pantox.com

Integrative Cancer Therapies

|May 11, 2006

Summary

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This study proposes an expanded nutraceutical program to combat cancer by targeting angiogenesis, metastasis, and immune function. The regimen includes specific supplements and dietary changes to improve patient outcomes.

Area of Science:

Nutritional Oncology
Cancer Therapeutics
Immunonutrition

Background:

Tumor-evoked angiogenesis can be impeded by a nutraceutical program including glycine, fish oil, epigallocatechin-3-gallate, selenium, and silymarin.
Existing strategies can be expanded to address common cancer patient needs like metastasis, immune defense, cachexia, thromboembolism, and osteolysis.

Purpose of the Study:

To propose an expanded nutraceutical program to address multiple aspects of cancer progression and patient support.
To integrate various supplements, dietary modifications, and exercise to enhance cancer treatment efficacy and patient well-being.

Main Methods:

Proposed inclusion of modified citrus pectin (galectin-3 antagonist) for antimetastatic effects.
Suggested use of mushroom beta-glucans and probiotic lactobacilli to enhance natural killer (NK) cell activity.

Related Experiment Videos

Incorporation of selenium, beta-carotene, glutamine, fish oil, policosanol, vitamin D, and salicylates for various anti-cancer effects.

Main Results:

The expanded program aims to block metastasis, boost NK cell cytotoxic capacity, prevent cachexia, thromboembolism, and tumor-induced osteolysis.
Salicylates may aid in preventing metastasis, cachexia, and osteolysis by inhibiting NF-κB activation, though with potential immune impacts.
A comprehensive nutritional insurance formula is proposed to maintain optimal micronutrient status for cancer patients.

Conclusions:

An integrated nutraceutical program, complemented by diet and exercise, offers a multifaceted approach to cancer management.
The proposed regimen, deliverable in convenient forms (oil, powder, capsules, tablets), warrants investigation in preclinical models.
Further research, including testing in nude mouse xenograft models, is needed to validate the efficacy of this comprehensive strategy.