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Gemcitabine-induced rectus abdominus radiation recall
1Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA. marwan.fakih@roswellpark.org
JOP : Journal of the Pancreas
|May 11, 2006
Summary
Radiation recall, a skin reaction, can also affect muscles during gemcitabine therapy after pancreatic cancer treatment. This rare side effect resolved after stopping gemcitabine, highlighting a potential complication for physicians to monitor.
Area of Science:
- Oncology
- Radiation Oncology
- Medical Oncology
Background:
- Radiation recall is a known phenomenon, often affecting the skin, particularly in patients undergoing chemotherapy.
- Gemcitabine is a commonly used chemotherapy agent, especially in the treatment of pancreatic cancer.
Observation:
- A case of radiation recall dermatitis and myositis is reported in a patient receiving gemcitabine monotherapy.
- This reaction occurred five months after completing chemoradiation for locally advanced pancreatic cancer.
Findings:
- The radiation recall involved both skin and rectus abdominus muscles.
- The symptoms resolved spontaneously upon discontinuation of gemcitabine treatment.
Implications:
- This case highlights gemcitabine-induced radiation recall myositis as a potential complication.
- Healthcare providers should be vigilant for this adverse event in patients treated with gemcitabine post-chemoradiation, especially for pancreatic cancer.