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Updated: Aug 8, 2026

Functional Assessment of Intestinal Tight Junction Barrier and Ion Permeability in Native Tissue by Ussing Chamber Technique
Published on: May 26, 2021
Tight junction proteins in the skin
J M Brandner1, S Kief, E Wladykowski
1Department of Dermatology and Venerology, University Hospital Hamburg-Eppendorf, Germany. brandner@uke.uni-hamburg.de
Abstract:
It has long been accepted that tight junctions (TJ) are crucial for the formation and maintenance of the paracellular barrier and for cell polarity in simple epithelia and endothelia. Moreover, it is long known that they play a role in barrier function of amphibian skin. However, only in recent years were TJ and TJ proteins identified in the epidermis of men and mice. Their involvement in the barrier function of mammalian skin has been shown. This review summarizes our current knowledge about TJ and TJ proteins in mammalian skin.
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