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Published on: July 25, 2011
[Experimental study of target-specific adriamycin nanoparticles in treating tongue squamous cell carcinoma]
Wu-long Jin1, Wei Guo, Wei-min Ye
1Department of Oral and Maxillofacial Surgery, School of Stomatology, Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China.
Purpose:
This study was designed to explore the method for increasing the target-specific action of anticancer agent in treating tongue squamous cell carcinoma.
Methods:
30 purebred New Zealand rabbits burdened with tongue squamous cell carcinoma were randomly divided into 2 groups. Group A was treated with adriamycin and group B treated with adriamycin nanoparticles, with 15 animals in each group. The adriamycin and poly (buty1-2-cyanoacrylate)-adriamycin nanoparticles (mean diameter 93.1 nm+/-11.7 nm) with 1 mg/ml in concentration were administered respectively to subjects through super-selective lingual arterial tuber. The dose was 2 mg/kg for each group. 1, 5 and 15 hours after administration, 5 subjects were sacrificed and the tongue, carcinoma in tongue tissue, heart, liver, spleen, kidney and plasma were examined through high performance liquid chromatography (HPLC) to identify the drug concentration. The data then underwent Student's t test.
Results:
The drug concentration in the tongue and carcinoma in group B were significantly higher than those in group A (P<0.01). The drug concentration in heart, liver, spleen, kidney and plasma of group B were significantly lower than those of group A (P<0.01).
Conclusion:
The super-selective lingual arterial administration of adriamycin nanoparticles can reinforce the target-specific action of anticancer agent, increase the drug concentration within the lesion and decrease it in non-specific organs.
Insights
Adriamycin nanoparticles significantly increased anticancer drug concentration in tongue tumors and reduced it in other organs. This method enhances targeted drug delivery for tongue squamous cell carcinoma treatment.
Area of Science:
- Oncology
- Nanomedicine
- Pharmacology
Background:
- Tongue squamous cell carcinoma (TSCC) presents a significant therapeutic challenge.
- Improving the targeted delivery of anticancer agents is crucial for enhancing treatment efficacy and minimizing systemic toxicity.
Purpose of the Study:
- To investigate the efficacy of adriamycin nanoparticles for targeted drug delivery in TSCC.
- To compare the drug distribution of adriamycin nanoparticles versus conventional adriamycin in tumor and non-target tissues.
Main Methods:
- A rabbit model of TSCC was established, with animals randomly assigned to receive either conventional adriamycin or adriamycin nanoparticles via super-selective lingual arterial administration.
- Drug concentrations in tumor tissue, tongue, and major organs (heart, liver, spleen, kidney) were quantified using high-performance liquid chromatography (HPLC) at various time points post-administration.
- Statistical analysis was performed using Student's t-test to compare drug distribution between the two groups.
Main Results:
- Adriamycin nanoparticles demonstrated significantly higher drug concentrations within the tongue and tumor tissues compared to conventional adriamycin (P<0.01).
- Conversely, adriamycin nanoparticles resulted in significantly lower drug concentrations in the heart, liver, spleen, kidney, and plasma (P<0.01).
Conclusions:
- Super-selective lingual arterial administration of adriamycin nanoparticles effectively enhances targeted drug delivery to TSCC.
- This nanomedicine approach increases intratumoral drug concentration while minimizing exposure to non-specific organs, suggesting improved therapeutic potential and reduced systemic side effects.
