Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Postural tremor suppression is dependent on thalamic stimulation frequency.

Mwiza Ushe1, Jonathan W Mink, Samer D Tabbal

  • 1Department of Neurology, Washington University, St. Louis, Missouri, USA.

Movement Disorders : Official Journal of the Movement Disorder Society
|May 11, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Blood-based circular RNAs for early diagnosis of Alzheimer's disease.

Nature medicine·2026
Same author

Multi-locus genetic dosage shapes cognitive disease progression in Parkinson's patients: 15-year meta-analysis of 24 cohorts.

NPJ Parkinson's disease·2026
Same author

Absolute Configuration and an Improved Automated cGMP Production of a Clinically Promising Radiotracer for Imaging VAChT.

Journal of fluorine chemistry·2026
Same author

Low overlap of plasma and CSF protein quantitative trait loci affects protein discovery for neurological disease.

Science translational medicine·2026
Same author

Kinetic Modeling of a Novel Putative Sphingosine-1-Phosphate Receptor 1 (S1PR1) Radiotracer [<sup>18</sup>F]TZ82112 in Nonhuman Primates.

Journal of neurochemistry·2026
Same author

Large-scale CSF and plasma proteomics reveal immune, synaptic, and extracellular matrix disruptions across neurodegenerative diseases.

Neuron·2026

Deep brain stimulation (DBS) for essential tremor (ET) using the ventral intermediate nucleus (VIM) is most effective at 100 Hz. Frequencies above this offer no additional tremor suppression but reduce battery life.

Area of Science:

  • Neurology
  • Neurosurgery
  • Biomedical Engineering

Background:

  • Essential tremor (ET) is a neurological disorder characterized by involuntary shaking.
  • Deep brain stimulation (DBS) of the ventral intermediate nucleus (VIM) is a common treatment for essential tremor.
  • The optimal stimulation frequency for tremor suppression in VIM DBS is not well-established.

Purpose of the Study:

  • To determine the relationship between stimulation frequency and tremor suppression in VIM DBS for essential tremor.
  • To identify the minimum effective stimulation frequency for tremor reduction.
  • To assess the impact of stimulation frequency on the longevity of implanted pulse generator batteries.

Main Methods:

  • Eleven patients with essential tremor undergoing VIM DBS were studied.

Related Experiment Videos

  • Tremor suppression was measured at various stimulation frequencies.
  • Short-term tremor suppression was assessed over three 15-second intervals for each frequency.

    • Main Results:

    • Maximal tremor suppression was achieved at stimulation frequencies of 100 Hz and above.
    • Frequencies higher than 100 Hz did not provide additional tremor suppression benefits.
    • Lowering stimulation frequency to 100 Hz could potentially extend battery life of the implanted pulse generator.

    Conclusions:

    • Essential tremor patients treated with VIM DBS may achieve adequate tremor control with stimulation frequencies around 100 Hz.
    • Using stimulation frequencies at or near 100 Hz, instead of commonly used higher settings, can prolong the battery life of VIM DBS devices.
    • This finding has implications for optimizing VIM DBS therapy and reducing the frequency of device replacement surgeries.