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Updated: Aug 8, 2026

In Vitro 3D Cell-Cultured Arterial Models for Studying Vascular Drug Targeting Under Flow
Published on: March 14, 2021
An in vitro patient-tailored model of human cerebral artery for simulating endovascular intervention
Seiichi Ikeda1, Fumihito Arai, Toshio Fukuda
1Dept. of Micro-Nano Systems Engineering, Nagoya Iniverisity, Furo-cho 1, Chikusa-ku, Nagoya, 464-8603, Japan. ikeda@robo.mein.nagoya-u.ac.jp
Abstract:
An in vitro patient-tailored reproduction model of cerebral artery, a hardware platform for simulating endovascular intervention for making diagnoses and surgical trainings is presented. 3-D configuration of vessel lumen is reproduced as vessel model with 13 microm modeling resolution, using CT and MRI information. Physical characteristics of cerebral artery, such as elastic modulus and friction coefficient, are also reproduced. We also propose a novel method to visualize stress condition on vessel wall using photoelastic effect. Consequently, it should be helpful for clinical applications, academic researches and other various purposes.

