Related Experiment Video
Updated: Aug 8, 2026
P50 Sensory Gating in Infants
Published on: December 26, 2013
[Sensory gating of patients with first-episode schizophrenia]
Xing-shi Chen1, Ming-dao Zhang, Hong-xing Wang
1Department of Electrophysiology, Shanghai Institute of Mental Health, Shanghai 200030, China.
Objective:
To investigate the characteristics of sensory gating P50 of patients with first-episode schizophrenia.
Methods:
The auditory evoked potentials P50 were recorded in 66 patients (Group Sch) with first-episode schizophrenia and 92 normal controls (Group NC) by using conditioning/testing paradigm presented with auditory double click stimuli.
Results:
The value of S1-P50 of Group Sch was 3 microV +/- 2 microV, significantly lower than that of Group NC (6 microV +/- 3 microV, P <0.01). The value of S2-P50 of Group Sch was 4 microV +/- 2 microV, significantly higher than that of Group NC (2 microV +/- 1 microV, P < 0.01). The S2/S1 ratio of Group Sc was 81% +/- 40%, significantly higher than that of Group NC (42% +/- 21%, P < 0.01). The value of S2 - S1 of Group Sch was 2 microV +/- 1 mciroV, significantly lower than that of Group Sch (3 mciroV +/- 2 microV). The value of 100 (1-S2/S1) of Group Sch was 19% +/- 17%, significantly lower than that of Group NC (58% +/- 21% , P < 0.01).
Conclusion:
Sensory gating deficit exists in the patients with first-episode schizophrenia, manifested in deficiency of inhibition that can be quantitatively observed by measuring auditory evoked potential P50.
