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A mathematical model describing the generation of oxygen radicals in mitochondria during ischemia-reperfusion
1Department of Protein Chemistry, Belozerskii Institute of Physicochemical Biology, Moscow State University, Russia.
Biomedical Science
|January 1, 1991
Abstract:
A mathematical model for the generation of free radicals by mitochondria in ischemia-reperfusion is proposed. Computations show that normally two stable equilibrium states exist: the intact state, and the state characterized by damage to mitochondrial structures and a high rate of radical formation. Transition from one state to another occurs after hypoxia of a certain degree of severity and duration. The model also describes a number of phenomena observed during development of reperfusion injuries and drug therapy.