Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[When translation arises from its TORpor].

Olivier Le Bacquer1, Yvan Martineau, Yaël Mamane

  • 1Laboratoire du Dr Nahum Sonenberg, Département de Biochimie, Université McGill, 3655, Promenade Sir-William-Osler, Montréal (Québec), H3G 1Y6 Canada.

Medecine Sciences : M/S
|May 12, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Structure and mechanism of inhibition of lysine demethylase 2A (KDM2A) by compound 183c.

Communications chemistry·2026
Same author

Src promotes tumor cell invasion by hijacking the translation machineries.

Cell reports·2026
Same author

Endocannabinoid system and skeletal muscle health: Insights from cannabidiol.

Molecular metabolism·2026
Same author

Molecular subtypes in pancreatic cancer: from academic promise to clinical reality.

Molecular cancer·2026
Same author

Drosophila melanogaster miPEP8 Regulates Cell Size Through its Interaction With ref(2)P/p62.

Molecular & cellular proteomics : MCP·2026
Same author

Src promotes tumor cell invasion by hijacking the translation machineries.

Cell reports·2026

Gene regulation impacts cellular balance, with disruptions linked to cancer, obesity, and diabetes. The PI3K/Akt/mTOR pathway and rapamycin show promise for novel therapeutic strategies.

Area of Science:

  • Molecular Biology
  • Cellular Biology
  • Medical Science

Background:

  • Gene regulation via transcriptional and post-translational mechanisms is crucial for cellular homeostasis.
  • Deregulation of gene expression is a known factor in diseases like cancer, obesity, and diabetes.
  • The PI3K/Akt/mTOR pathway's role in translation initiation has been increasingly recognized in disease development.

Purpose of the Study:

  • To review the role of gene regulation, particularly translation initiation via the PI3K/Akt/mTOR pathway, in cellular homeostasis and disease.
  • To highlight the therapeutic potential of rapamycin, an mTOR inhibitor, in various pathologies.

Main Methods:

  • Literature review focusing on gene regulation mechanisms.
  • Analysis of studies investigating the PI3K/Akt/mTOR pathway.

Related Experiment Videos

  • Examination of research on rapamycin's effects in cancer, obesity, and diabetes.

    • Main Results:

    • Transcriptional deregulation is implicated in major diseases.
    • The PI3K/Akt/mTOR pathway significantly controls translation initiation.
    • Rapamycin exhibits anti-proliferative effects in cancer and potential benefits in obesity and diabetes.

    Conclusions:

    • Rapamycin and its analogs represent a promising therapeutic avenue.
    • Targeting the PI3K/Akt/mTOR pathway offers potential for novel treatment strategies.
    • Further development of rapamycin-based therapies is warranted for diverse diseases.