Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Imaging today's infectious animalcules.

Freddy Frischknecht1, Olivier Renaud, Spencer L Shorte

  • 1Department of Parasitology, University of Heidelberg Medical School, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany.

Current Opinion in Microbiology
|May 12, 2006
PubMed
Summary

Advancements in optical microscopy, including quantitative imaging, enable detailed studies of host-pathogen interactions. Customized imaging methods overcome challenges, opening new research avenues in microbiology.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Widespread use of invalid statistical tests in biomedical machine learning.

bioRxiv : the preprint server for biology·2026
Same author

[Transitioning to digital pathology: Feedback from the eNovA-Path project of the 3 university hospitals of Nouvelle Aquitaine (Poitiers, Limoges and Bordeaux)].

Annales de pathologie·2025
Same author

Do you look longer at attractive faces? It depends on what you are looking for.

i-Perception·2024
Same author

Acceleration of cutaneous T-cell lymphoma mistaken for atopic dermatitis following JAK inhibitor use.

European journal of dermatology : EJD·2024
Same author

MuscleJ2: a rebuilding of MuscleJ with new features for high-content analysis of skeletal muscle immunofluorescence slides.

Skeletal muscle·2023
Same author

Relationship between reward-related brain activity and opportunities to sit.

Cortex; a journal devoted to the study of the nervous system and behavior·2023

Area of Science:

  • Microbiology
  • Cell Biology
  • Optical Microscopy

Background:

  • Optical microscopy has significantly advanced the study of pathogens and host cell interactions.
  • Microbiology benefits from modern imaging technologies like digital and confocal microscopy, but faces unique challenges.
  • Customized imaging methods are crucial for overcoming these challenges in microbial research.

Purpose of the Study:

  • To explore the application of state-of-the-art quantitative imaging methods for probing host-pathogen interactions at the single-cell level.
  • To highlight the innovative use of combined microscopy techniques and advanced labeling for high-throughput experimentation.
  • To demonstrate how adapted imaging methodologies expand research possibilities in microbiology.

Main Methods:

Related Experiment Videos

  • Utilizing combined light and electron microscopy.
  • Employing bi-arsenical tetra-cysteine tag labeling for precise visualization.
  • Implementing automated image acquisition and analysis for high-throughput and high-content screening.

    • Main Results:

    • Demonstrated the successful application of advanced imaging techniques to study host-pathogen interactions.
    • Showcased the efficacy of combined microscopy and labeling strategies for detailed cellular analysis.
    • Validated automated image analysis for efficient high-throughput experimentation in microbiology.

    Conclusions:

    • Adapted imaging methodologies are essential for advancing host-pathogen interaction studies.
    • Quantitative imaging and automated analysis provide unprecedented insights into single-cell microbial processes.
    • These innovative imaging approaches open previously inaccessible research avenues in microbiology.