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Related Experiment Videos

Bisphosphonate-associated mandibular osteonecrosis.

E Carneiro1, P Vibhute, A Montazem

  • 1Department of Neuroradiology, Sao Joao Hospital, Porto, Portugal.

AJNR. American Journal of Neuroradiology
|May 12, 2006
PubMed
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Severe jaw osteonecrosis occurred in a multiple myeloma patient treated with zoledronic acid, a bisphosphonate. This condition, osteonecrosis of the jaw, was unresponsive to antibiotics, highlighting potential bisphosphonate-related complications.

Area of Science:

  • Oncology
  • Pharmacology
  • Oral Surgery

Background:

  • Multiple myeloma is a hematologic malignancy.
  • Zoledronic acid is a bisphosphonate medication used in multiple myeloma treatment.
  • Osteonecrosis of the jaw (ONJ) is a known potential side effect of bisphosphonate therapy.

Observation:

  • A 66-year-old male patient with multiple myeloma underwent tooth extraction.
  • The patient received treatment including zoledronic acid, melphalan, and prednisone.
  • Following treatment, the patient developed severe, antibiotic-resistant osteonecrosis of the mandible.

Findings:

  • Computed tomography (CT) scan revealed extensive fragmented sequestra within the mandible.
  • Soft tissue swelling adjacent to the mandible was also noted.

Related Experiment Videos

  • The clinical presentation was consistent with medication-related osteonecrosis of the jaw.

    • Implications:

    • This case underscores the importance of recognizing bisphosphonate-associated osteonecrosis of the jaw (ONJ).
    • Dental management in patients receiving bisphosphonates requires careful consideration.
    • Early recognition and management strategies are crucial for patients with ONJ.