Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Structure and visualization of high-dimensional conductance spaces.

Adam L Taylor1, Timothy J Hickey, Astrid A Prinz

  • 1Volen Center, Brandeis University, Waltham, MA 02454, USA.

Journal of Neurophysiology
|May 12, 2006
PubMed
Summary

Understanding how neuron conductances affect intrinsic properties is key. Clutter-based dimension reordering (CBDR) visualizes these complex relationships in neuronal models, aiding research.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Plasticity in thoracic paravertebral sympathetic postganglionic neurons after high spinal cord transection.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same author

Compensation of the effects of temperature on a motor system in the crab, <i>Cancer borealis</i>.

bioRxiv : the preprint server for biology·2026
Same author

Sensitivity of a model oscillator to shifts in the voltage-dependence of one or more ionic currents.

Journal of neurophysiology·2026
Same author

Blue plaque review series: Thomas Graham Brown: Before his time.

Experimental physiology·2026
Same author

Quantitative Neuropeptidomics Reveals Thermal Acclimation-Induced Remodeling of Peptidergic Signaling in the American Lobster <i>Homarus americanus</i>.

bioRxiv : the preprint server for biology·2026
Same author

Temperature and pH-dependent potassium currents of muscles of the stomatogastric nervous system of the crab, <i>Cancer borealis</i>.

iScience·2026

Area of Science:

  • Computational Neuroscience
  • Systems Neuroscience
  • Biophysics

Background:

  • Neurons possess diverse voltage-gated conductances crucial for their function.
  • These conductances undergo continuous regulation, impacting neuronal intrinsic properties.
  • Visualizing how maximal conductances influence properties like firing delay is challenging.

Purpose of the Study:

  • To develop and apply a novel visualization technique for high-dimensional conductance spaces in neuronal models.
  • To understand the relationship between maximal conductances and intrinsic neuronal properties.
  • To demonstrate the utility of the technique for analyzing and visualizing complex datasets.

Main Methods:

  • Utilized clutter-based dimension reordering (CBDR) for visualization.

Related Experiment Videos

  • Applied CBDR to a family of neuronal models with eight distinct voltage- and calcium-dependent channels.
  • Integrated CBDR with connected-components and linear classifier analyses.

    • Main Results:

    • CBDR effectively visualizes structure within high-dimensional conductance spaces.
    • The technique reveals how variations in maximal conductances correlate with intrinsic neuronal properties.
    • CBDR successfully visualizes results from other analytical methods, such as connected-components and hyperplane analyses.

    Conclusions:

    • Clutter-based dimension reordering (CBDR) is a powerful tool for exploring neuronal conductance spaces.
    • This method aids in understanding the impact of conductance regulation on neuronal function.
    • CBDR offers a valuable approach for visualizing complex data in computational neuroscience research.