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Synthesis and structure-activity relationships of 2',3'-dideoxypurine nucleosides as potential antiretroviral agents
E Kojima1, T Shirasaka, M Machida
1Research Laboratory of Bioresources, Sanyo-Kokusaku Pulp Co. Ltd, Iwakuni, Japan.
Nucleic Acids Symposium Series
|January 1, 1991
Abstract:
In order to study the structure-activity relationships of 2',3'-dideoxypurine nucleosides as potential anti-retroviral agents, various purine derivatives have been synthesized and tested against rous sarcoma virus (RSV) in chick embryo fibroblast (CEF) cells, and against human immunodeficiency virus (HIV) in human CD4+ T cells (ATH8). Some of the new purine derivatives found to be significant antiretroviral activities. And the correlations of activity between anti-RSV and anti-HIV have shown fairly good values so far.