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Increased systemic T-lymphocyte reactivity in patients with established stroke
E Tarkowski1, P Ekelund, A Tarkowski
1Department of Clinical Immunology, University of Göteborg, Sweden.
Journal of Clinical & Laboratory Immunology
|August 1, 1991
Summary
Stroke enhances immune T-cell responses, both in vivo and in vitro, as measured by delayed-type hypersensitivity (DTH) reactions and cell proliferation. However, B-cell function remains unaffected by stroke.
Area of Science:
- Immunology
- Neurology
- Stroke Research
Background:
- Stroke, characterized by hemiparesis and sensory loss, can significantly impact immune system functions.
- Understanding the post-stroke immune response is crucial for patient recovery and management.
Purpose of the Study:
- To investigate the effects of stroke on systemic in vivo and in vitro immune functions.
- To assess T-cell reactivity using delayed-type hypersensitivity (DTH) and in vitro proliferation assays.
- To evaluate T-cell dependent B-cell function following influenza vaccination.
Main Methods:
- Assessed DTH reaction to purified protein derivative (PPD) in stroke patients and controls.
- Measured in vitro proliferative responses of peripheral blood mononuclear cells to PPD and Concanavalin A.
- Analyzed serum antibody responses (IgG, IgA, IgM) after influenza vaccine immunization.
Main Results:
- Stroke patients showed a significantly higher incidence of positive DTH reactions to PPD compared to controls (46% vs. 24%).
- In vitro, 50% of stroke patients exhibited proliferative responses to PPD, versus 20% in controls.
- Both stroke patients and controls demonstrated comparable antibody responses after influenza vaccination.
Conclusions:
- Stroke enhances systemic antigen-specific T-cell reactivity, both in vivo and in vitro.
- Stroke does not appear to significantly affect antigen-specific B-cell responses or antibody production.