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Related Experiment Videos

Microfluidics/CMOS orthogonal capabilities for cell biology.

Vincent Linder1, Sander Koster, Wendy Franks

  • 1SAMLAB, Institute of Microtechnology, University of Neuchâtel, Switzerland.

Biomedical Microdevices
|May 12, 2006
PubMed
Summary

This study presents a novel microfluidic flow cell integrating CMOS technology for precise electrical and pharmacological cell stimulation. The device enables spatially resolved drug delivery to electrogenic cells, advancing cellular research.

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Area of Science:

  • Biomedical Engineering
  • Cellular Electrophysiology
  • Microfluidics

Background:

  • Microfabricated devices are crucial for stimulating and recording electrical cellular events.
  • Existing devices face challenges integrating microfluidics with miniaturized CMOS chips.

Purpose of the Study:

  • To develop an integrated device combining CMOS technology and microfluidics for advanced cell stimulation and recording.
  • To overcome size mismatches between microfluidic systems and CMOS chips.
  • To enable localized drug delivery and study electrogenic mammalian cells.

Main Methods:

  • Designed and simulated a 3-D microfluidic flow cell accommodating a CMOS chip.
  • Fabricated the microfluidic flow cell with six individual drug inlets and nutrient flow.

Related Experiment Videos

  • Experimentally verified nutrient and drug delivery performance using mass transfer analysis.

    • Main Results:

    • The microfluidic flow cell successfully integrated CMOS technology for signal processing and microfluidics for drug delivery.
    • Experimental results for nutrient and drug flow mass transfer closely matched simulations.
    • Demonstrated spatially resolved drug delivery to HL-1 cardiac myocytes.

    Conclusions:

    • The developed microfluidic flow cell effectively addresses the integration challenges between microfluidics and CMOS technology.
    • This device offers a powerful platform for studying electrogenic cells with precise control over stimulation and drug delivery.
    • The technology holds significant potential for advancing research in cellular electrophysiology and drug screening.