Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

DNASER I: layout and data analysis.

Claudio Nicolini1, Andrea Marco Malvezzi, Alessandra Tomaselli

  • 1Department of Biophysical MO Sciences and Technologies, University of Genoa, Genoa 16132, Italy. cn.roma@tin.it

IEEE Transactions on Nanobioscience
|May 13, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Long-term cardiac effects of adrenalectomy versus surveillance in mild cortisol excess: 5-year results from the prospective ITACA study.

European journal of endocrinology·2026
Same author

Adrenal causes of endocrine hypertension in childhood or adolescence.

Journal of endocrinological investigation·2025
Same author

Chronotherapy With Once-Daily Osilodrostat Improves Cortisol Rhythm, Quality of Life, and Sleep in Cushing's Syndrome.

The Journal of clinical endocrinology and metabolism·2025
Same author

Exploring the interplay of karyotype, hormones, sexuality, and body image perception in individuals with Turner syndrome.

Journal of endocrinological investigation·2025
Same author

Impact of Female Sex and Mild Cortisol Secretion on Coagulation Profile in Adrenal Incidentalomas.

Journal of the Endocrine Society·2024
Same author

Exploring sexual function in adrenal insufficiency: findings from the Dual RElease hydrocortisone versus conventionAl glucocorticoid replaceMent therapy in hypocortisolism (DREAM) trial.

Andrology·2024
Same journal

A Transparent, Microfluidic Lab On A Chip For Multi-Modal Cell Culture Monitoring For Neurotoxicity Research.

IEEE transactions on nanobioscience·2026
Same journal

Investigating Effect of Dimensional Variance on Separation of Glomerular Ultrafiltrate in a Microfluidic Environment.

IEEE transactions on nanobioscience·2026
Same journal

Green synthesis of multifunctional ZnFe<sub>2</sub>O<sub>4</sub>-MWCNT-Cellulose acetate nanocomposite for peroxidase enzyme immobilization.

IEEE transactions on nanobioscience·2026
Same journal

IoT-Enabled SnO₂-Based Humidity Sensor for Real-Time Monitoring in Neonatal Incubators.

IEEE transactions on nanobioscience·2026
Same journal

Electrokinetic and Antibiofilm Effects of Silver Nanoparticles Combined with Imipenem Against multidrug-resistant of Klebsiella pneumoniae.

IEEE transactions on nanobioscience·2026
Same journal

Bio-inspired Optofluidic Molecular Communication with Photothermally Actuated Microrobot Swarms.

IEEE transactions on nanobioscience·2026
See all related articles

We developed the DNA analyzer (DNASER), a new instrument for rapid, high-quality imaging and automated analysis of fluorescent DNA microarrays, improving upon traditional methods for DNA chip spot evaluation.

Area of Science:

  • Bioinstrumentation
  • Microarray Technology
  • Image Analysis

Background:

  • Traditional DNA microarray analysis is time-consuming and requires predefined geometry.
  • Existing imaging systems may lack speed and image quality.
  • Automated, high-resolution DNA microarray analysis is needed.

Purpose of the Study:

  • To introduce the DNA analyzer (DNASER), a novel bioinstrumentation system.
  • To enable real-time image acquisition and processing of fluorescent DNA microarrays.
  • To provide automated analysis of DNA chip spots without prior geometric information.

Main Methods:

  • Utilizing a white light beam for sample illumination.
  • Employing a high-sensitivity, wide-band charge-coupled device camera (ORCA II-Hamamatsu) for image capture.

Related Experiment Videos

  • Implementing automated image processing for spot recognition, distribution analysis, and property evaluation.

    • Main Results:

    • The DNASER achieves faster image acquisition with higher quality compared to traditional systems.
    • Automated analysis of DNA chip spots is demonstrated, requiring no prior geometric data.
    • Preliminary experimental results on real DNA samples show promising performance.

    Conclusions:

    • The DNASER offers a significant advancement in DNA microarray imaging and analysis.
    • Its automated, high-performance capabilities streamline the study of DNA microarrays.
    • This technology has the potential to enhance research involving fluorescent DNA microarrays.