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Updated: Aug 8, 2026

Quantifying Acute Changes in Renal Sympathetic Nerve Activity in Response to Central Nervous System Manipulations in Anesthetized Rats
Published on: September 11, 2018
[Role of sympathoadrenal activations in congestive heart failure]
1Cardiology Division, Department of Medicine, Keio University School of Medicine.
Abstract:
Although sympathoneuronal activation plays a major role in maintaining circulatory homeostasis in decompensated heart failure, protracted activation adversely affects survival in patients with chronic heart failure. Endstage heart failure is associated with beta-adrenergic receptor subsensitivity phenomenon including downregulation of beta1-adrenergic receptors, uncoupling induced by receptor kinase activations, increased level of inhibitory guanine nucleotide binding protein. Abnormal calcium handling occurs as a result of dissociation of ryanodine receptors and its modulatory protein, FK506 binding proteins in addition to defective calcium uptake. Phosphoinositide 3-kinase gamma as well as defective neuronal uptake mechanism of norepinephrine have a pivotal role in mediating these alterations in adrenergic receptor signalings. In this regards, modulation of excessive adrenergic activations is essential to achieve successful management of patients with congestive heart failure.
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