Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Cardiac aldosterone].

Michihiro Yoshimura1

  • 1Department of Cardiovascular Medicine, Kumamoto University School of Medicine.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|May 13, 2006
PubMed
Summary
This summary is machine-generated.

The failing heart secretes aldosterone, while normal hearts secrete dehydroepiandrosterone (DHEA). Both conditions involve heart-secreted adrenocorticotropic hormone (ACTH), indicating local hormone production.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

"Flying Saucer"-Like Morphology in Infective Endocarditis Arising on a Stenotic Mitral Valve.

JACC. Case reports·2026
Same author

Association of neutrophil-to-lymphocyte ratio (NLR) with the infarct size in acute myocardial infarction (AMI), through peak creatine kinase (CK) and peak creatine kinase-myocardial band (CK-MB): A retrospective observational study.

Medicine·2025
Same author

Exacerbation and cardiopulmonary risk after prompt initiation of single-inhaler budesonide /glycopyrrolate/formoterol fumarate following COPD exacerbations: Insights from MITOS EROS (Japan) study.

Respiratory investigation·2025
Same author

Real-time detection of microembolic signals using carotid echocardiography: A comparative study of 3 pulsed-field systems.

Heart rhythm·2025
Same author

Correlation Between decreased mixed venous oxygen saturation and increased B-type natriuretic peptides independent of hemodynamics in pre-heart failure/heart failure patients.

Peptides·2025
Same author

The Importance of CT Angiography in Detecting Impending Paradoxical Embolism in Patients With Pulmonary Embolism.

JACC. Case reports·2025
Same journal

[Development of novel therapeutics for multiple myeloma and improvement of drug lag].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[Clinical pharmacy services to patients of immunomodulatory drugs].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[Therapeutic drug monitoring of the new anti-myeloma drugs in the treatment of multiple myeloma].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[Prognostic value of minimal residual disease assessment using next-generation sequencing in multiple myeloma].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[The evaluation of minimal residual disease in multiple myeloma by an allele-specific oligonucleotide real-time PCR].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[Evaluation of minimal residual disease in myeloma by multiparametric flow cytometry].

Nihon rinsho. Japanese journal of clinical medicine·2019
See all related articles

Area of Science:

  • Cardiology
  • Endocrinology
  • Molecular Biology

Background:

  • The heart compensates for functional deterioration in heart failure through hormonal actions.
  • Emerging evidence indicates that failing or hypertensive hearts synthesize and secrete various hormones.
  • Previous research suggests the presence of steroid synthesis within the heart.

Purpose of the Study:

  • To investigate the differential secretion of aldosterone and dehydroepiandrosterone (DHEA) by normal versus failing hearts.
  • To determine the presence and secretion of adrenocorticotropic hormone (ACTH) from the failing or hypertensive heart.
  • To explore the potential presence of hormones from the hypothalamus-pituitary-adrenal (HPA) axis and the renin-angiotensin-aldosterone (RAA) system within the heart.

Main Methods:

Related Experiment Videos

  • Comparative analysis of hormone secretion profiles from normal and failing/hypertensive heart tissue.
  • Measurement of aldosterone and DHEA levels in cardiac secretions.
  • Detection of ACTH and other HPA axis/RAA system components in cardiac tissue and secretions.

    • Main Results:

    • Failing hearts secrete aldosterone but not DHEA.
    • Normal hearts secrete DHEA but not aldosterone.
    • Both failing and hypertensive hearts secrete ACTH.

    Conclusions:

    • The heart exhibits distinct patterns of steroid hormone secretion depending on its functional state (normal vs. failure/hypertension).
    • Adrenocorticotropic hormone (ACTH) is secreted by the failing or hypertensive heart.
    • These findings suggest that key components of the hypothalamus-pituitary-adrenal (HPA) axis and the renin-angiotensin-aldosterone (RAA) system are locally present and active within the heart.