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Related Experiment Videos

Gestational nicotine-induced changes in adolescent neuronal activity.

Minjung K Park1, Sandra E Loughlin, Frances M Leslie

  • 1Department of Pharmacology, School of Medicine, University of California, Irvine, CA 92697-4625, USA. minjungp@uci.edu

Brain Research
|May 13, 2006
PubMed
Summary

Gestational nicotine exposure alters basal neuronal activity in key brain regions of adolescent offspring. This may explain behavioral deficits seen in children of mothers who smoked during pregnancy.

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Pharmacology

Background:

  • Smoking during pregnancy leads to infant neurobehavioral deficits.
  • Understanding the mechanisms of these deficits is crucial.

Purpose of the Study:

  • To investigate the effects of gestational nicotine exposure on neuronal activity in adolescent offspring.
  • To assess c-fos mRNA expression as a marker of neuronal activity.

Main Methods:

  • Pregnant rats were administered nicotine or saline.
  • Offspring brains were analyzed for c-fos mRNA expression using in situ hybridization.
  • Neuronal activity was measured in response to acute nicotine challenge.

Main Results:

  • Gestational nicotine did not alter acute nicotine-induced c-fos expression.

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  • Basal c-fos expression was increased in the infralimbic cortex and nucleus accumbens core.
  • Acute nicotine challenge affected c-fos expression in several brain regions.

    • Conclusions:

    • Gestational nicotine exposure alters basal neuronal activity in mesocorticolimbic structures.
    • These alterations may underlie attention, cognition, and impulse control deficits in offspring.
    • This research provides insight into the neurobiological consequences of prenatal smoking.