Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Associating functional recovery with neurocognitive profiles identified using partially ordered classification

Judith Jaeger1, Curtis Tatsuoka, Stefanie Berns

  • 1Center for Neuropsychiatric Outcome and Rehabilitation Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA. jaeger.ju@verizon.net

Schizophrenia Research
|May 13, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

External validation as the critical step for predictive biomarkers.

The international journal of neuropsychopharmacology·2026
Same author

Backfill Bayesian Ordered Lattice Design for Phase I Clinical Trials.

medRxiv : the preprint server for health sciences·2026
Same author

The Clinically Meaningful Score Difference and Meaningful Score Regions in Positive and Negative Syndrome Scale Total Score from Post Hoc Analyses of a Phase 3 Pivotal Clinical Trial of Transdermal Asenapine in Patients with Schizophrenia.

Neuropsychiatric disease and treatment·2026
Same author

Brief Report: Multi-Institution Real-World Analysis Evaluating Safety, Efficacy, and ctDNA Dynamics After Tarlatamab in Patients With Previously Treated SCLC and LCNEC.

JTO clinical and research reports·2026
Same author

High-density EEG study in patients with schizophrenia treated with cariprazine.

The international journal of neuropsychopharmacology·2026
Same author

Bayesian Ordered Lattice Design for Phase I Clinical Trials.

Statistics in medicine·2026

Identifying specific neurocognitive functions linked to schizophrenia outcomes is crucial for effective treatment. This study found working memory impacts work/education, while other cognitive skills affect residential functioning.

Area of Science:

  • Psychiatry
  • Neuroscience
  • Cognitive Psychology

Background:

  • Neurocognitive deficits are central to schizophrenia, causing significant functional disability.
  • Conventional neuropsychological tests are polyfactorial, complicating the identification of specific cognitive deficits.
  • Understanding which cognitive operations drive functional recovery is essential for targeted schizophrenia treatments.

Purpose of the Study:

  • To investigate the association between distinct neurocognitive profiles and specific domains of functional outcome in schizophrenia.
  • To determine if different cognitive operations differentially predict work/education versus residential functioning.

Main Methods:

  • Applied Bayesian statistical methods (partially ordered sets/posets) to classify 220 schizophrenia patients into unique cognitive profiles.

Related Experiment Videos

  • Assessed attributes including working memory, divergent thinking, cognitive flexibility, and psychomotor speed.
  • Correlated these cognitive profiles with work/education and residential functioning outcomes assessed up to 18 months later.

    • Main Results:

    • Working memory was significantly associated with work/education outcomes after multiplicity correction.
    • Working memory was not associated with residential functioning.
    • Cognitive flexibility, divergent thinking, and psychomotor speed were associated with residential functioning outcomes.

    Conclusions:

    • Different neurocognitive operations may underpin distinct domains of functional recovery in schizophrenia.
    • The poset methodology is valuable for clarifying relationships between neurocognitive attributes and functional outcomes.
    • Findings support tailored treatment approaches targeting specific cognitive deficits for improved functional recovery in schizophrenia.