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New analogues of butylated hydroxytoluene as anti-inflammatory and antioxidant agents
George N Ziakas1, Eleni A Rekka, Antonios M Gavalas
1Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotelian University of Thessaloniki, Greece.
Bioorganic & Medicinal Chemistry
|May 13, 2006
Abstract:
Amine or amide derivatives bearing the 2,6-di-tert-butyl phenol moiety are synthesised. Almost all are antioxidants, reduce acute inflammation and inhibit COX-1 and lipoxygenase activity. The most potent anti-inflammatory, COX-1 inhibitor and antioxidant agent, with low toxicity, is 2,6-di-tert-butyl-4-thiomorpholin-4-ylmethyl-phenol.