Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Reference range for serum parathyroid hormone.

John F Aloia1, Martin Feuerman, James K Yeh

  • 1Bone Mineral Research Center, Winthrop University Hospital, Mineola, New York 11501, USA.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
|May 13, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Vitamin D supplementation to prevent acute respiratory infections: systematic review and meta-analysis of stratified aggregate data.

The lancet. Diabetes & endocrinology·2025
Same author

Expression of concern to: Effects of growth hormone on bone modeling and remodeling in hypophysectomized young female rats: a bone histomorphometric study.

Journal of bone and mineral metabolism·2021
Same author

Editorial Expression of Concern: Differential effects of growth hormone and alfa calcidol on trabecular and cortical bones in hypophysectomized rats.

Pediatric research·2021
Same author

Vitamin D supplementation to prevent acute respiratory infections: a systematic review and meta-analysis of aggregate data from randomised controlled trials.

The lancet. Diabetes & endocrinology·2021
Same author

Vitamin D supplementation to prevent acute respiratory infections: systematic review and meta-analysis of aggregate data from randomised controlled trials.

medRxiv : the preprint server for health sciences·2020
Same author

Retraction of "Effect of Deconditioning on Cortical and Cancellous Bone Growth in the Exercise Trained Young Rats".

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2020
Same journal

Tirzepatide versus conventional GLP-1 receptor agonists for treatment simplification in type 2 diabetes mellitus: a real-world study.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·2026
Same journal

Risk-stratification of pediatric thyroid nodules using ATA and ACR TIRADS adult thyroid nodule scoring systems.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·2026
Same journal

Effectiveness of GLP-1 receptor agonists and SGLT-2 inhibitors combination therapy in type 2 diabetes: a real world experience.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·2026
Same journal

North American Society for Interventional Thyroidology (NASIT) Statement on Directed Ablative Therapy for the Management of of Low Risk Papillary Thyroid Carcinoma.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·2026
Same journal

Lower Cutoffs Improve the Diagnostic Performance of DDAVP-Stimulated Bilateral Inferior Petrosal Sinus Sampling for Cushing Disease: A Prospective Cohort Study.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·2026
Same journal

Efficacy of Initiation of Semaglutide versus SGLT2 inhibitors in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): A Multicenter Propensity-Matched Real-World Study.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·2026
See all related articles

The reference range for parathyroid hormone (PTH) should not be lowered. Factors like obesity, race, and vitamin D levels influence PTH and should be considered for accurate interpretation.

Area of Science:

  • Endocrinology
  • Clinical Chemistry

Background:

  • The established reference range for parathyroid hormone (PTH) is being re-evaluated.
  • A proposed lower upper limit of 46 pg/mL for PTH has been suggested, potentially impacting clinical interpretation.

Purpose of the Study:

  • To determine if the reference range for serum parathyroid hormone (PTH) should be lowered using the Allegro radioimmunometric assay.
  • To assess the validity of a proposed upper PTH limit of 46 pg/mL.

Main Methods:

  • Examined PTH reference range adjusted for serum 25-hydroxyvitamin D (25-OHD) in 503 healthy women (African American and white, aged 20-80).
  • Analyzed various factors influencing PTH levels, including body mass index, age, race, serum creatinine, dietary calcium, and 25-OHD levels.
  • Utilized univariate and multivariate analyses, including stepwise multiple linear regression.

Related Experiment Videos

Main Results:

  • Serum PTH levels were significantly higher in Black participants compared to White participants (P<0.02).
  • Increasing PTH correlated with higher body mass index, age, and serum creatinine, and lower dietary calcium intake and 25-OHD levels.
  • Body mass index (R2=9.4%), age (R2=1.0%), and serum 25-OHD (R2=0.8%) were significant predictors of PTH in the multivariate model.

Conclusions:

  • The upper limit of the reference range for serum PTH should not be changed from the current standard.
  • Clinical interpretation of elevated PTH in normocalcemic patients should consider obesity, race, 25-OHD levels, advanced age, serum creatinine, and dietary calcium intake.