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Related Experiment Videos

Glycemic relapse in type 2 diabetes.

Alan L Graber1, Ayumi K Shintani, Kathleen Wolff

  • 1Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
|May 13, 2006
PubMed
Summary

Most patients with type 2 diabetes experience glycemic relapse after intensive treatment. Insulin therapy increases relapse risk, highlighting the need for continued intensive care and relapse prevention strategies.

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Area of Science:

  • Endocrinology
  • Metabolic Diseases
  • Diabetes Management

Background:

  • Intensive interventions can improve glycemic control in type 2 diabetes.
  • Understanding relapse patterns is crucial for long-term disease management.

Purpose of the Study:

  • To determine the rate of glycemic relapse after an intensive outpatient intervention for type 2 diabetes.
  • To identify predictors associated with glycemic relapse.

Main Methods:

  • Analysis of 393 type 2 diabetes patients achieving glycemic control (hemoglobin A1c <7%) post-intervention.
  • Follow-up for a median of 26.5 months, defining relapse as A1c ≥7%.

Main Results:

  • Glycemic relapse occurred in 45% at 1 year and 76% at 3 years, with a median time to relapse of 15.2 months.

Related Experiment Videos

  • Insulin treatment was linked to a 1.5-fold increased risk of relapse (HR=1.5).
  • Shorter diabetes duration and weight loss during intervention reduced relapse risk in non-insulin users.

    • Conclusions:

    • A majority of type 2 diabetes patients relapse after intensive glycemic control.
    • Insulin therapy is a significant risk factor for glycemic relapse.
    • Patients on insulin require prioritized follow-up and relapse prevention interventions.