Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Errors in thyroid gland fine-needle aspiration.

Stephen S Raab1, Colleen M Vrbin, Dana Marie Grzybicki

  • 1Department of Pathology, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15232, USA.

American Journal of Clinical Pathology
|May 13, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Interpretive Diagnostic Error Reduction: Guideline Update from the College of American Pathologists in Collaboration With the Association of Directors of Anatomic and Subspecialty Pathology.

Archives of pathology & laboratory medicine·2026
Same author

Detection of actionable mutations in the cerebrospinal fluid and concordance/discordance with extracranial mutations in patients with metastatic breast cancer and leptomeningeal disease.

Therapeutic advances in medical oncology·2026
Same author

FNA biopsy of breast specimens effectively harvests cells for patient-derived organoids modeling ductal carcinoma in situ.

Cancer cytopathology·2025
Same author

The utility of next-generation sequencing in metastatic prostate cancer FNA biopsies.

Cancer cytopathology·2025
Same author

Pathologist performed ultrasound guided fine needle aspiration (US-FNA): current status, trends, and insights from the American Society of Cytopathology Sponsored Survey.

Journal of the American Society of Cytopathology·2025
Same author

American Society of Cytopathology (ASC) study group recommendations for practicing ultrasound guided-fine needle aspiration (US-FNA).

Journal of the American Society of Cytopathology·2025
Same journal

Invasive urothelial carcinoma in association with surface low-grade papillary urothelial carcinoma: clinical and pathologic insights from a rare entity.

American journal of clinical pathology·2026
Same journal

CEACAM1 expression by immunohistochemistry in B-cell lymphomas and plasma cell myeloma.

American journal of clinical pathology·2026
Same journal

Comprehensive multicriteria life cycle assessment of biopsy processing in a surgical pathology department.

American journal of clinical pathology·2026
Same journal

Prognostic significance of Myb protein and its downstream target genes in lacrimal gland adenoid cystic carcinoma.

American journal of clinical pathology·2026
Same journal

Mismatch repair protein "nonclassic expression loss" pattern in colorectal cancer: an important staining pattern that is not well understood.

American journal of clinical pathology·2026
Same journal

Musculoskeletal pain in medical laboratory personnel: a cross-sectional study.

American journal of clinical pathology·2026
See all related articles

Improving thyroid fine-needle aspiration accuracy requires addressing specimen quality and interpretation errors. This study identified key issues and proposed solutions to reduce diagnostic mistakes in pathology practice.

Area of Science:

  • Pathology
  • Patient Safety
  • Diagnostic Accuracy

Background:

  • Limited data exists on pathology practice redesign using error analysis.
  • Patient safety initiatives are crucial for improving diagnostic performance.

Purpose of the Study:

  • To measure performance metrics for thyroid fine-needle aspiration.
  • To conduct a root cause analysis of diagnostic errors.
  • To propose error-reduction initiatives for pathology practice.

Main Methods:

  • Analysis of 1,543 thyroid gland aspirates over two years.
  • Surgical pathology follow-up for 364 patients to determine diagnostic accuracy.
  • Root cause analysis to identify sources of pre-analytic and analytic errors.

Related Experiment Videos

Main Results:

  • A 25.0% false-negative rate and a 9.9% false-positive rate were observed.
  • Major error sources included poor specimen quality (pre-analytic) and interpretation of unsatisfactory specimens (analytic).
  • Lack of diagnostic category standardization was also identified as an analytic error source.

Conclusions:

  • Thyroid fine-needle aspiration performance can be significantly impacted by pre-analytic and analytic factors.
  • Targeting specimen quality and interpretation standardization is essential for error reduction.
  • Ongoing evaluation of error reduction initiatives is underway to enhance diagnostic pathway reliability.