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Procarbazine for non-Hodgkin's lymphoma
Bassem T Chaar1, Pascale Salem, Paul J Petruska
1Department of Internal Medicine, Saint Louis University School of Medicine, Saint Louis, MO 63110, USA. chaarbt@slu.edu
Leukemia & Lymphoma
|May 13, 2006
Summary
Procarbazine hydrochloride, an oral alkylating agent, can induce durable remissions in refractory follicular lymphoma. This study highlights its potential in treating relapsed or refractory non-Hodgkin
Area of Science:
- Oncology
- Pharmacology
- Hematology
Background:
- Procarbazine hydrochloride is an oral alkylating agent historically used for lymphoma treatment.
- Its use in non-Hodgkin's lymphoma declined with the introduction of CHOP chemotherapy.
- Follicular lymphoma is an indolent non-Hodgkin's lymphoma that can become refractory to standard treatments.
Purpose of the Study:
- To evaluate the efficacy of a prolonged course of daily procarbazine in patients with relapsed or refractory follicular lymphoma.
Main Methods:
- Case report of two patients with relapsed and/or refractory follicular lymphoma.
- Treatment involved a prolonged course of daily procarbazine hydrochloride.
Main Results:
- Both patients achieved a complete and durable remission.
- The treatment was well-tolerated, allowing for a prolonged administration.
Conclusions:
- A prolonged course of daily procarbazine hydrochloride can be an effective treatment option for selected patients with relapsed or refractory follicular lymphoma.
- This approach may offer a valuable alternative when standard therapies fail.
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