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Updated: Aug 8, 2026

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

Elevated plasma active matrix metalloproteinase-9 level is associated with coronary artery in-stent restenosis

Gregory T Jones1, I Patrick Kay, J W S Chu

  • 1Section of Surgery, University of Otago, Dunedin, New Zealand. greg.jones@otago.ac.nz

Arteriosclerosis, Thrombosis, and Vascular Biology
|May 13, 2006
PubMed

Insights

Plasma active matrix metalloproteinase-9 (MMP-9) levels are elevated in patients with in-stent restenosis (ISR). Higher active MMP-9 levels independently predict ISR, especially in bare metal stents.

Area of Science:

  • Cardiovascular Biology
  • Biomarkers
  • Interventional Cardiology

Background:

  • In-stent restenosis (ISR) is a significant complication following coronary stenting.
  • Identifying reliable biomarkers for ISR is crucial for patient management.
  • Matrix metalloproteinases (MMPs) and their inhibitors are implicated in vascular remodeling.

Purpose of the Study:

  • To investigate plasma levels of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinases-1 (TIMP-1) in patients with a history of symptomatic ISR.
  • To determine if these biomarkers are associated with ISR development.

Main Methods:

  • A case-control study comparing 158 patients with ISR history to 128 symptom-free controls.
  • Analysis of plasma for pro-MMP-9, latent MMP-9, active MMP-9, latent MMP-3, and TIMP-1.
  • Assessment of clinical variables including coronary disease extent, stent characteristics, and lipid profiles.

Main Results:

  • Plasma active MMP-9 levels were significantly higher in patients with ISR.
  • Active MMP-9 demonstrated an independent risk association with ISR (OR, 1.96; 95% CI, 1.43-2.69).
  • Patients with multiple ISR lesions had elevated active MMP-9 compared to those with single or no ISR.

Conclusions:

  • Plasma active MMP-9 may serve as a valuable independent predictor for bare metal stent ISR.
  • Further research could explore the clinical utility of active MMP-9 in risk stratification for ISR.
Abstract

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