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Updated: Aug 8, 2026

A Mouse Distraction Osteogenesis Model
Published on: November 14, 2018
A case of Paget's disease treated by distraction osteogenesis
Takanobu Nakase1, Kenji Ohzono, Nobuhito Araki
1Department of Orthopaedic Surgery, National Hospital Organization Osaka National Hospital, Osaka, Japan. tnakase@ff.iij4u.or.jp
Abstract:
Paget's disease is a localized bone disorder marked by increased turnover usually associated with a deformity of the affected bone. Distraction osteogenesis may be a useful method for correcting the deformity. A 57-year-old woman with Paget's disease had a 3 cm limb-length discrepancy with a 47 degrees procurvatum deformity of the ipsilateral femur. Distraction osteogenesis using a Taylor Spatial Frame was performed, leading to complete correction of the procurvatum deformity and limb-length discrepancy. After improvement of the limb-length discrepancy, the patient felt more comfortable than she had before surgery with less low back pain. This result suggests distraction osteogenesis may be appropriate for the treatment of some severe, complex deformities of the lower limbs in patients with Paget's disease.
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